Article
pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum.
Molecular microbiology - 1 Aug 2005
Sidhu Amar Bir Singh, Valderramos Stephanie Gaw, Fidock David A
Abstract excerpt
The emergence and spread of multidrug resistant Plasmodium falciparum has severely limited the therapeutic options for the treatment of malaria. With ever-increasing failure rates associated with chloroquine or sulphadoxine-pyrimethamine treatment, attention has turned to the few alternatives, wh...
Topics
- ATP-Binding Cassette Transporters
- Alleles
- Animals
- Antimalarials
- Artemisinins
- Asparagine
- Aspartic Acid
- Drug Resistance
- Mefloquine
- Phenanthrenes
- Plasmodium falciparum
- Point Mutation
- Protozoan Proteins
- Quinine
- Sesquiterpenes