Article
Rapid identification of genes controlling virulence and immunity in malaria parasites.
PLoS pathogens - 1 Jul 2017
Abkallo Hussein M, Martinelli Axel, Inoue Megumi, Ramaprasad Abhinay, Xangsayarath Phonepadith, Gitaka Jesse, Tang Jianxia, Yahata Kazuhide, Zoungrana Augustin, Mitaka Hayato, Acharjee Arita, Datta Partha P, Hunt Paul, Carter Richard, Kaneko Osamu, Mustonen Ville, Illingworth Christopher J R, Pain Arnab, Culleton Richard
Abstract excerpt
Identifying the genetic determinants of phenotypes that impact disease severity is of fundamental importance for the design of new interventions against malaria. Here we present a rapid genome-wide approach capable of identifying multiple genetic drivers of medically relevant phenotypes within malaria parasites via a single experiment at single gene or allele resolution. In a proof of principle study, we found...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.