Article
Oncolytic adenovirus expressing a p53 variant resistant to degradation by HPV E6 protein exhibits potent and selective replication in cervical cancer.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Dec 2005
Heideman Daniëlle A M, Steenbergen Renske D M, van der Torre Jaco, Scheffner Martin, Alemany Ramon, Gerritsen Winald R, Meijer Chris J L M, Snijders Peter J F, van Beusechem Victor W
Abstract excerpt
Rationale in the development of novel treatment strategies for HPV-associated cancers is targeting on the basis of the presence of HPV in (pre)malignant cells. Here, we designed a new conditionally replicating adenovirus (CRAd) for selective and effective oncolytic replication in HPV-containing cells. As the backbone, we used the CRAd AdCB016, which replicates selectively in cells expressing HPV E6 and E7...
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