Engineering regulatory elements for conditionally-replicative adeno-viruses.

doi:10.2174/1566523034578311

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Engineering regulatory elements for conditionally-replicative adeno-viruses.

Current gene therapy - 1 Aug 2003

Haviv Yosef S, Curiel David T

Abstract excerpt

Virus-mediated oncolysis is a rapidly growing field with the potential to dramatically alter the future of cancer therapy. Replication-selective viruses are superior to non-replicating vectors in several aspects, such as the amplification of the initial low-dose viral inoculum up to 10(3)-10(3)-fold, lateralization into neighboring cells, introduction of novel cell killing mechanisms, and a potential for a safe...

Topics

Adenoviridae
Adenovirus E1A Proteins
Adenovirus E3 Proteins
Animals
Antineoplastic Agents
DNA Replication
Enhancer Elements, Genetic
Gene Deletion
Genetic Therapy
Genetic Vectors
Genome, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Models, Biological

Models, Genetic

Mutation

Neoplasms

Virus Replication

Source

Open in PubMed

Identifiers

PMID: 12871022
DOI: 10.2174/1566523034578311

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Engineering regulatory elements for conditionally-replicative adeno-viruses.PMID 12871022Read ↗

Modified adenoviruses for cancer gene therapySemantic proximity Read ↗

Adenoviruses for treatment of cancerSemantic proximity Read ↗

Current Developments In Adenovirus-Based Cancer Gene TherapySemantic proximity Read ↗

Concepts in Oncolytic Adenovirus TherapySemantic proximity Read ↗

Designing adenoviral vectors for tumor-specific targeting.Semantic proximity Read ↗

A conditionally replicating adenovirus with strict selectivity in killing cells expressing epidermal growth factor receptor.Semantic proximity Read ↗

Evolving Horizons: Adenovirus Vectors’ Timeless Influence on Cancer, Gene Therapy and VaccinesSemantic proximity Read ↗

Adenovirus Biology, Recombinant Adenovirus, and Adenovirus Usage in Gene TherapySemantic proximity Read ↗

Designer Oncolytic Adenovirus: Coming of AgeSemantic proximity Read ↗

Replicative Oncolytic Adenoviruses in Multimodal Cancer RegimensSemantic proximity Read ↗

Conditionally Replicating Adenoviruses Expressing Short Hairpin RNAs Silence the Expression of a Target Gene in Cancer CellsSemantic proximity Read ↗

Triple-Targeted Oncolytic Adenoviruses Featuring the Cox2 Promoter, E1A Transcomplementation, and Serotype Chimerism for Enhanced Selectivity for Ovarian Cancer CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.