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Article

Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate.

Structure (London, England : 1993) - 1 Aug 2005

Batra Vinod K, Beard William A, Shock David D, Pedersen Lars C, Wilson Samuel H

Abstract excerpt

DNA polymerases occasionally insert the wrong nucleotide. For this error to become a mutation, the mispair must be extended. We report a structure of DNA polymerase beta (pol beta) with a DNA mismatch at the boundary of the polymerase active site. The structure of this complex indicates that the templating adenine of the mispair stacks with the primer terminus adenine while the templating (coding) cytosine is...

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Identifiers

PMID: 16084394
DOI: 10.1016/j.str.2005.05.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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