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Article

Substrate-induced DNA polymerase β activation.

The Journal of biological chemistry - 7 Nov 2014

Beard William A, Shock David D, Batra Vinod K, Prasad Rajendra, Wilson Samuel H

Abstract excerpt

DNA polymerases and substrates undergo conformational changes upon forming protein-ligand complexes. These conformational adjustments can hasten or deter DNA synthesis and influence substrate discrimination. From structural comparison of binary DNA and ternary DNA-dNTP complexes of DNA polymerase β, several side chains have been implicated in facilitating formation of an active ternary complex poised for...

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Identifiers

PMID: 25261471
DOI: 10.1074/jbc.M114.607432
PMCID: PMC4223340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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