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Article

An interaction network in the polymerase active site is a prerequisite for Watson-Crick base pairing in Pol γ.

Science advances - 24 May 2024

Park Joon, Herrmann Geoffrey K, Roy Arkanil, Shumate Christie K, Cisneros G Andrés, Yin Y Whitney

Abstract excerpt

The replication accuracy of DNA polymerase gamma (Pol γ) is essential for mitochondrial genome integrity. Mutation of human Pol γ arginine-853 has been linked to neurological diseases. Although not a catalytic residue, Pol γ arginine-853 mutants are void of polymerase activity. To identify the structural basis for the disease, we determined a crystal structure of the Pol γ mutant ternary complex with correct...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38787958
DOI: 10.1126/sciadv.adl3214
PMCID: PMC11122685

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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