Article
Genotype-phenotype relationships in an investigation of the role of proteases in abdominal aortic aneurysm expansion.
The British journal of surgery - 1 Nov 2005
Eriksson P, Jormsjö-Pettersson S, Brady A R, Deguchi H, Hamsten A, Powell J T
Abstract excerpt
BACKGROUND: The aim of the study was to investigate the effect of functional polymorphisms in promoters of matrix metalloproteinase (MMP) 2, MMP-3, MMP-9, MMP-12 and plasminogen activator inhibitor (PAI) 1 genes on the growth rate of small abdominal aortic aneurysms (AAA). METHODS: Some 455 individuals with a small AAA (4.0-5.5 cm) were monitored for aneurysm growth by ultrasonography (mean follow-up 2.6 years)....
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