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Article

Genetic approach to the role of cysteine proteases in the expansion of abdominal aortic aneurysms.

The British journal of surgery - 1 Jan 2004

Eriksson P, Jones K G, Brown L C, Greenhalgh R M, Hamsten A, Powell J T

Abstract excerpt

BACKGROUND: The elastinolytic cysteine proteases, including cathepsins S and K, are overexpressed at sites of arterial elastin damage. Cystatin C, an inhibitor of these enzymes, is expressed in arterial smooth muscle cells; an imbalance in cystatin C has been implicated in the aortic wall degeneration observed in abdominal aortic aneurysms (AAAs). The aim of the study was to investigate the impact of a...

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Identifiers

PMID: 14716800
DOI: 10.1002/bjs.4364
PMCID: PMC11439999

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Source receipt: pubmed, retrieved 7 Sept 2026.

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