Activation of NF-κB by the Kaposi's Sarcoma-Associated Herpesvirus K15 Protein Involves Recruitment of the NF-κB-Inducing Kinase, IκB Kinases, and Phosphorylation of p65

Abstract excerpt

UNLABELLED: Kaposi's sarcoma herpesvirus (KSHV) (or human herpesvirus 8) is the cause of Kaposi's sarcoma, primary effusion lymphoma (PEL), and the plasma cell variant of multicentric Castleman's disease (MCD). The transmembrane K15 protein, encoded by KSHV, has been shown to activate NF-κB and the mitogen-activated protein kinases (MAPKs) c-jun-N-terminal kinase (JNK) and extracellular signal-regulated kinase...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Inflammasome and immune disorders
• Share to NF-κB Signaling Pathways
• Share to Viral-associated cancers and disorders