Article
p53 codon 72 genotype affects apoptosis by cytosine arabinoside in blood leukocytes.
Biochemical and biophysical research communications - 13 Dec 2002
Bonafè Massimiliano, Salvioli Stefano, Barbi Cristiana, Mishto Michele, Trapassi Chiara, Gemelli Claudia, Storci Gianluca, Olivieri Fabiola, Monti Daniela, Franceschi Claudio
Abstract excerpt
A wide difference in the susceptibility to undergo in vitro apoptosis exists among individuals, and this fact has potential implications in predicting the in vivo response to apoptotic agents, such as those employed in chemotherapy. In this report, we addressed the question whether the natural variability at p53 locus (the proline-arginine substitution at codon 72) affects the capacity of peripheral-blood...
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