Article
The potential role of epigenomic dysregulation in complex human disease.
Trends in genetics : TIG - 1 Nov 2007
Hatchwell Eli, Greally John M
Abstract excerpt
One of the major challenges in genetics today is to understand the causes of complex genetic diseases. The genes involved in these disorders are thought to interact with poorly-defined environmental factors to exert their phenotypic effects. An emerging view is that epigenetics also plays a role in complex diseases. Here we review the evidence that epigenetic regulatory mediators can be influenced by several...
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