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The variation game: Cracking complex genetic disorders with NGS and omics data.

Methods (San Diego, Calif.) - 1 Jun 2015

Cui Hongzhu, Dhroso Andi, Johnson Nathan, Korkin Dmitry

Abstract excerpt

Tremendous advances in Next Generation Sequencing (NGS) and high-throughput omics methods have brought us one step closer towards mechanistic understanding of the complex disease at the molecular level. In this review, we discuss four basic regulatory mechanisms implicated in complex genetic diseases, such as cancer, neurological disorders, heart disease, diabetes, and many others. The mechanisms, including...

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PMID: 25944472
DOI: 10.1016/j.ymeth.2015.04.018

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