Article

Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc

2024-10-13

Abstract excerpt

Cellular senescence, characterized by a permanent state of cell cycle arrest and a secretory phenotype contributing to inflammation and tissue deterioration, has emerged as a target for age-related interventions. Accumulation of senescent cells is closely linked with intervertebral disc (IVD) degeneration, a prevalent age-dependent chronic disorder causing low back pain. Previous studies have highlighted that plat...

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Literature Corpus work: 1a851602-e6fe-5864-b349-b5020de78442
DOI: 10.1101/2024.10.11.617862

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