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Article

Human expanded polyglutamine androgen receptor mutants in neurodegeneration as a novel ligand target.

The Journal of pharmacology and experimental therapeutics - 1 Nov 2005

Furutani Takashi, Takeyama Ken-ichi, Tanabe Masahiko, Koutoku Hiroshi, Ito Saya, Taniguchi Nobuaki, Suzuki Eriko, Kudoh Masafumi, Shibasaki Masayuki, Shikama Hisataka, Kato Shigeaki

Abstract excerpt

Androgen receptor (AR) plays key roles in various biological events, including pathological processes such as prostate cancer, androgen-insensitive syndrome, and spinal and bulbar muscular atrophy (SBMA). SBMA is caused by mutation of the expanded polyglutamine (polyQ) stretches in the AR gene. R...

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PMID: 16079302
DOI: 10.1124/jpet.105.087643

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16079302-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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