Article
RNA-binding protein hoip accelerates polyQ-induced neurodegeneration in Drosophila.
Bioscience, biotechnology, and biochemistry - 1 Sept 2008
Murata Takuya, Suzuki Eriko, Ito Saya, Sawatsubashi Shun, Zhao Yue, Yamagata Kaoru, Tanabe Masahiko, Fujiyama Sally, Kimura Shuhei, Ueda Takashi, Matsukawa Hiroyuki, Kouzmenko Alexander, Furutani Takashi, Kuranaga Erina, Miura Masayuki, Takeyama Ken-ichi, Kato Shigeaki
Abstract excerpt
Abnormal polyglutamine (polyQ) expansion in the N-terminal domain of the human androgen receptor (hAR) is known to cause spinobulbar muscular atrophy (SBMA), a hereditary human neurodegenerative disorder. To explore the molecular mechanisms of neurodegeneration in SBMA, we genetically screened modulators of neurodegeneration in a Drosophila SBMA experimental model system. We identified hoip as an accelerator of...
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