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Article

Silencing neuronal mutant androgen receptor in a mouse model of spinal and bulbar muscular atrophy.

Human molecular genetics - 1 Nov 2015

Sahashi Kentaro, Katsuno Masahisa, Hung Gene, Adachi Hiroaki, Kondo Naohide, Nakatsuji Hideaki, Tohnai Genki, Iida Madoka, Bennett C Frank, Sobue Gen

Abstract excerpt

Spinal and bulbar muscular atrophy (SBMA), an adult-onset neurodegenerative disease that affects males, results from a CAG triplet repeat/polyglutamine expansions in the androgen receptor (AR) gene. Patients develop progressive muscular weakness and atrophy, and no effective therapy is currently available. The tissue-specific pathogenesis, especially relative pathological contributions between degenerative motor...

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Source

Identifiers

PMID: 26231218
DOI: 10.1093/hmg/ddv300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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