Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A genetic screen targeting the tumor necrosis factor/Eiger signaling pathway: identification of Drosophila TAB2 as a functionally conserved component.

Genetics - 1 Dec 2005

Geuking Peter, Narasimamurthy Rajesh, Basler Konrad

Abstract excerpt

Signaling by tumor necrosis factors (TNFs) plays a prominent role in mammalian development and disease. To fully understand this complex signaling pathway it is important to identify all regulators and transduction components. A single TNF family member, Eiger, is encoded in the Drosophila genome, offering the possibility of applying genetic approaches for pursuing this goal. Here we present a screen for the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Genetic Vectors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoblotting

Share to Immunoprecipitation

Share to Luciferases

Share to MAP Kinase Kinase Kinases

Share to Suppression, Genetic

Share to TNF Receptor-Associated Factor 1

Source

Open in PubMed Open full text

Identifiers

PMID: 16079232
DOI: 10.1534/genetics.105.045534
PMCID: PMC1456095

Genes

TNF
TAB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A genetic screen targeting the tumor necrosis factor/Eiger signaling pathway: identification of Drosophila TAB2 as a functionally conserved component.PMID 16079232Read ↗

Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway.Semantic proximity Read ↗

Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for Eiger signaling.Semantic proximity Read ↗

Discrete functions of TRAF1 and TRAF2 in Drosophila melanogaster mediated by c-Jun N-terminal kinase and NF-kappaB-dependent signaling pathways.Semantic proximity Read ↗

TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd.Semantic proximity Read ↗

The <i>Drosophila</i> TNF Eiger contributes to Myc super-competition independent of JNK activitySemantic proximity Read ↗

Candidate EDA targets revealed by expression profiling of primary keratinocytes from Tabby mutant mice.Semantic proximity Read ↗

A non-redundant role for Drosophila Mkk4 and hemipterous/Mkk7 in TAK1-mediated activation of JNK.Semantic proximity Read ↗

Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila.Semantic proximity Read ↗

TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development.Semantic proximity Read ↗

Early embryonic lethality caused by targeted disruption of the TRAF-interacting protein (TRIP) gene.Semantic proximity Read ↗

The Drosophila TNF ortholog eiger is required in the fat body for a robust immune response.Semantic proximity Read ↗

EDA targets revealed by skin gene expression profiles of wild-type, Tabby and Tabby EDA-A1 transgenic mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.