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Article

The lipopolysaccharide of Brucella abortus BvrS/BvrR mutants contains lipid A modifications and has higher affinity for bactericidal cationic peptides.

Journal of bacteriology - 1 Aug 2005

Manterola Lorea, Moriyón Ignacio, Moreno Edgardo, Sola-Landa Alberto, Weiss David S, Koch Michel H J, Howe Jörg, Brandenburg Klaus, López-Goñi Ignacio

Abstract excerpt

The two-component BvrS/BvrR system is essential for Brucella abortus virulence. It was shown previously that its dysfunction abrogates expression of some major outer membrane proteins and increases bactericidal peptide sensitivity. Here, we report that BvrS/BvrR mutants have increased surface hydrophobicity and susceptibility to killing by nonimmune serum. The bvrS and bvrR mutant lipopolysaccharides (LPSs) bound...

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Identifiers

PMID: 16077108
DOI: 10.1128/JB.187.16.5631-5639.2005
PMCID: PMC1196083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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