Article
Extensive cell envelope modulation is associated with virulence in Brucella abortus.
Journal of proteome research - 1 Apr 2007
Lamontagne Julie, Butler Heather, Chaves-Olarte Esteban, Hunter Joanna, Schirm Michael, Paquet Caroline, Tian Mei, Kearney Paul, Hamaidi Lyes, Chelsky Daniel, Moriyón Ignacio, Moreno Edgardo, Paramithiotis Eustache
Abstract excerpt
Brucella virulence is linked to components of the cell envelope and tightly connected to the function of the BvrR/BvrS sensory-regulatory system. To quantify the impact of BvrR/BvrS on cell envelope proteins, we performed a label-free mass spectrometry-based proteomic analysis of spontaneously released outer membrane fragments from four strains of Brucella abortus (wild type virulent, avirulent bvrR- and bvrS-...
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