Article
Mutations of the quorum sensing-dependent regulator VjbR lead to drastic surface modifications in Brucella melitensis.
Journal of bacteriology - 1 Aug 2007
Uzureau Sophie, Godefroid Marie, Deschamps Chantal, Lemaire Julien, De Bolle Xavier, Letesson Jean-Jacques
Abstract excerpt
Successful establishment of infection by bacterial pathogens requires fine-tuning of virulence-related genes. Quorum sensing (QS) is a global regulation process based on the synthesis of, detection of, and response to small diffusible molecules, called N-acyl-homoserine lactones (AHL), in gram-negative bacteria. In numerous species, QS has been shown to regulate genes involved in the establishment of pathogenic...
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