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Article

Distinct roles for key karyogamy proteins during yeast nuclear fusion.

Molecular biology of the cell - 1 Sept 2009

Melloy Patricia, Shen Shu, White Erin, Rose Mark D

Abstract excerpt

During yeast mating, cell fusion is followed by the congression and fusion of the two nuclei. Proteins required for nuclear fusion are found at the surface (Prm3p) and within the lumen (Kar2p, Kar5p, and Kar8p) of the nuclear envelope (NE). Electron tomography (ET) of zygotes revealed that mutations in these proteins block nuclear fusion with different morphologies, suggesting that they act in different steps of...

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Identifiers

PMID: 19570912
DOI: 10.1091/mbc.e09-02-0163
PMCID: PMC2735476

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