Article

BmK rAGAP inhibits breast cancer cell proliferation, migration, and invasion by downregulating SCN5A expression and subsequent AKT and MAPK activation.

2022-05-26

Abstract excerpt

BACKGROUND Bm K rAGAP is voltage-gated sodium ion channel-like scorpion venom peptides, which have anti-tumor activity. Voltage-gated sodium ion channels subunit SCN5A was highly expressed in MDA-MB-231 and it was associated with breast cancer malignancy. METHODS AND RESULTS In order to explore the effect of Bm K rAGAP on MDA-MB-231 and its possible mechanism, the data were downloaded based on TCGA to analyze gene...

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Literature Corpus work: 3b8aa942-39b2-54df-b517-af8f028b4776
DOI: 10.21203/rs.3.rs-1653492/v1

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