Article
The Voltage-Gated Sodium Channel Beta4 Subunit Maintains Epithelial Phenotype in Mammary Cells.
Cells - 29 Jun 2021
Doray Adélaïde, Lemoine Roxane, Severin Marc, Chadet Stéphanie, Lopez-Charcas Osbaldo, Héraud Audrey, Baron Christophe, Besson Pierre, Monteil Arnaud, Pedersen Stine Falsig, Roger Sébastien
Abstract excerpt
The SCN4B gene, coding for the NaVβ4 subunit of voltage-gated sodium channels, was recently found to be expressed in normal epithelial cells and down-regulated in several cancers. However, its function in normal epithelial cells has not been characterized. In this study, we demonstrated that reducing NaVβ4 expression in MCF10A non-cancer mammary epithelial cells generated important morphological changes observed...
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