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Article

Inhibition of initiation of reverse transcription in HIV-1 by human APOBEC3F

25 Apr 2007

Abstract excerpt

Vif-negative HIV-1 produced in non-permissive human cells incorporate both APOBEC3F (hA3F) AND APOBEC3G (hA3G), and have a severely reduced ability to produce viral DNA in newly infected cells. While it has been proposed that this reduction is due to deamination of deoxycytidine in viral DNA by either hA3G or hA3F, followed by DNA degradation, recent evidence indicates that the inhibition of viral DNA production...

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Identifiers

PMID: 17459442
DOI: 10.1016/j.virol.2007.03.022

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Inhibition of initiation of reverse transcription in HIV-1 by human APOBEC3FPMID 17459442Read ↗

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