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Article

Generation and phenotypic analysis of mice lacking all urea transporters.

Kidney international - 1 Feb 2017

Jiang Tao, Li Yingjie, Layton Anita T, Wang Weiling, Sun Yi, Li Min, Zhou Hong, Yang Baoxue

Abstract excerpt

Urea transporters (UT) are a family of transmembrane urea-selective channel proteins expressed in multiple tissues and play an important role in the urine concentrating mechanism of the mammalian kidney. UT inhibitors have diuretic activity and could be developed as novel diuretics. To determine if functional deficiency of all UTs in all tissues causes physiological abnormality, we established a novel mouse model...

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Identifiers

PMID: 27914708
DOI: 10.1016/j.kint.2016.09.017
PMCID: PMC5423716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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