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Molecular implications of the human glutathione transferase A-4 gene (hGSTA4) polymorphisms in neurodegenerative diseases.

Mutation research - 11 Nov 2005

Coppedè Fabio, Armani Chiara, Bidia Damiana Della, Petrozzi Lucia, Bonuccelli Ubaldo, Migliore Lucia

Abstract excerpt

Several lines of evidence, including an increased level of lipid peroxidation and the depletion of antioxidant molecules like as glutathione (GSH), indicate that oxidative stress plays an important role in the pathogenesis of several neurodegenerative disorders, such as Parkinson's disease (PD) and Alzheimer's disease (AD). We previously observed a significant increased level of DNA oxidative damage in peripheral...

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Identifiers

PMID: 16054170
DOI: 10.1016/j.mrfmmm.2005.02.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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