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Article

Evolution of human immunodeficiency virus type 1 protease genotypes and phenotypes in vivo under selective pressure of the protease inhibitor ritonavir.

Journal of virology - 1 Aug 2005

Resch Wolfgang, Parkin Neil, Watkins Terri, Harris Janera, Swanstrom Ronald

Abstract excerpt

We examined the population dynamics of human immunodeficiency virus type 1 pro variants during the evolution of resistance to the protease inhibitor ritonavir (RTV) in vivo. pro variants were followed in subjects who had added RTV to their previously failed reverse transcriptase inhibitor therapy using a heteroduplex tracking assay designed to detect common resistance-associated mutations. In most cases the...

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Share to Acquired Immunodeficiency Syndrome
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Products, gag

Share to Heteroduplex Analysis

Share to HIV Protease

Share to HIV Protease Inhibitors

Share to Ritonavir

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Source

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Identifiers

PMID: 16051856
DOI: 10.1128/JVI.79.16.10638-10649.2005
PMCID: PMC1182672

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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