Resistance-associated loss of viral fitness in human immunodeficiency virus type 1: phenotypic analysis of protease and gag coevolution in protease inhibitor-treated patients.

Abstract excerpt

We have studied the phenotypic impact of adaptative Gag cleavage site mutations in patient-derived human immunodeficiency virus type 1 (HIV-1) variants having developed resistance to the protease inhibitor ritonavir or saquinavir. We found that Gag mutations occurred in a minority of resistant vi...

Topics

• Amino Acid Sequence
• Anti-HIV Agents
• Cell Line, Transformed
• Drug Resistance, Microbial
• Evolution, Molecular
• Gene Products, gag
• HIV Infections
• HIV Protease
• HIV Protease Inhibitors
• HIV-1
• HeLa Cells
• Humans
• Molecular Sequence Data
• Phenotype
• Ritonavir
• Saquinavir