Article
Rapid evolutionary escape by large populations from local fitness peaks is likely in nature.
Evolution; international journal of organic evolution - 1 Jun 2005
Weinreich Daniel M, Chao Lin
Abstract excerpt
Fitness interactions between loci in the genome, or epistasis, can result in mutations that are individually deleterious but jointly beneficial. Such epistasis gives rise to multiple peaks on the genotypic fitness landscape. The problem of evolutionary escape from such local peaks has been a central problem of evolutionary genetics for at least 75 years. Much attention has focused on models of small populations,...
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