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Article

Fitness-valley crossing with generalized parent-offspring transmission.

Theoretical population biology - 1 Nov 2015

Osmond Matthew M, Otto Sarah P

Abstract excerpt

Simple and ubiquitous gene interactions create rugged fitness landscapes composed of coadapted gene complexes separated by "valleys" of low fitness. Crossing such fitness valleys allows a population to escape suboptimal local fitness peaks to become better adapted. This is the premise of Sewall Wright's shifting balance process. Here we generalize the theory of fitness-valley crossing in the two-locus, bi-allelic...

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Identifiers

PMID: 26321054
DOI: 10.1016/j.tpb.2015.08.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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