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Article

The rate at which asexual populations cross fitness valleys.

Theoretical population biology - 1 Jun 2009

Weissman Daniel B, Desai Michael M, Fisher Daniel S, Feldman Marcus W

Abstract excerpt

Complex traits often involve interactions between different genetic loci. This can lead to sign epistasis, whereby mutations that are individually deleterious or neutral combine to confer a fitness benefit. In order to acquire the beneficial genotype, an asexual population must cross a fitness valley or plateau by first acquiring the deleterious or neutral intermediates. Here, we present a complete, intuitive...

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Identifiers

PMID: 19285994
DOI: 10.1016/j.tpb.2009.02.006
PMCID: PMC2992471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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