Article
Emergent neutrality in adaptive asexual evolution.
Genetics - 1 Dec 2011
Schiffels Stephan, Szöllosi Gergely J, Mustonen Ville, Lässig Michael
Abstract excerpt
In nonrecombining genomes, genetic linkage can be an important evolutionary force. Linkage generates interference interactions, by which simultaneously occurring mutations affect each other's chance of fixation. Here, we develop a comprehensive model of adaptive evolution in linked genomes, which integrates interference interactions between multiple beneficial and deleterious mutations into a unified framework....
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