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Article

Competition between recombination and epistasis can cause a transition from allele to genotype selection.

Proceedings of the National Academy of Sciences of the United States of America - 21 Apr 2009

Neher Richard A, Shraiman Boris I

Abstract excerpt

Biochemical and regulatory interactions central to biological networks are expected to cause extensive genetic interactions or epistasis affecting the heritability of complex traits and the distribution of genotypes in populations. However, the inference of epistasis from the observed phenotype-genotype correlation is impeded by statistical difficulties, while the theoretical understanding of the effects of...

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Identifiers

PMID: 19366665
DOI: 10.1073/pnas.0812560106
PMCID: PMC2672512

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Source receipt: pubmed, retrieved 7 Sept 2026.

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