Genetic polymorphisms in carcinogen metabolism and their association to hereditary nonpolyposis colon cancer.

doi:10.1016/s0016-5085(98)70017-4

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Article

Genetic polymorphisms in carcinogen metabolism and their association to hereditary nonpolyposis colon cancer.

Gastroenterology - 1 Dec 1998

Moisio A L, Sistonen P, Mecklin J P, Järvinen H, Peltomäki P

Abstract excerpt

BACKGROUND & AIMS: The phenotype of hereditary nonpolyposis colorectal cancer shows interfamilial and intrafamilial variation even in the presence of identical predisposing mutations, suggesting the existence of additional phenotype determinants. The modifying role of genetic polymorphisms in loc...

Topics

Adult
Age of Onset
Colorectal Neoplasms, Hereditary Nonpolyposis
Genotype
Humans
Middle Aged
Mutation
Polymorphism, Genetic

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