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Article

Genetic polymorphisms in carcinogen metabolism and their association to hereditary nonpolyposis colon cancer.

Gastroenterology - 1 Dec 1998

Moisio A L, Sistonen P, Mecklin J P, Järvinen H, Peltomäki P

Abstract excerpt

BACKGROUND & AIMS: The phenotype of hereditary nonpolyposis colorectal cancer shows interfamilial and intrafamilial variation even in the presence of identical predisposing mutations, suggesting the existence of additional phenotype determinants. The modifying role of genetic polymorphisms in loci involved in carcinogen metabolism was studied. METHODS: We focused on colon cancers from kindreds sharing one of two...

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Source

Identifiers

PMID: 9834266
DOI: 10.1016/s0016-5085(98)70017-4

Genes

GSTT1
NAT1
GSTM1
MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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