Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glomerular aging in females is a multi-stage reversible process mediated by phenotypic changes in progenitors.

The American journal of pathology - 1 Aug 2005

Feng Zheng, Plati Anna Rita, Cheng Qing-li, Berho Mariana, Banerjee Anita, Potier Mylene, Jy Wen-che, Koff Andrew, Striker Liliane J, Striker Gary E

Abstract excerpt

The glomeruli of postmenopausal C57BL6 mice, and age-matched males, show progressive hypertrophy and glomerulosclerosis. We asked whether this was a multistage process, was due to alterations in glomerular progenitors, and was reversible in female mice. Using cross bone marrow transplants (BMT) between young and old females, we found that BMT delivered a phenotype that was donor age-specific. The fact that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Transplantation
Share to Cyclin-Dependent Kinase Inhibitor p21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p27

Share to Glomerular Mesangium

Share to Hypertrophy

Share to Kidney Glomerulus

Share to Matrix Metalloproteinase 2

Share to Sclerosis

Source

Open in PubMed Open full text

Identifiers

PMID: 16049323
DOI: 10.1016/S0002-9440(10)62981-1
PMCID: PMC1603557

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glomerular aging in females is a multi-stage reversible process mediated by phenotypic changes in progenitors.PMID 16049323Read ↗

The glomerulosclerosis of aging in females: contribution of the proinflammatory mesangial cell phenotype to macrophage infiltration.Semantic proximity Read ↗

Sex-specific modulation of renal epigenetic and injury markers in aging kidneySemantic proximity Read ↗

Cells derived from young bone marrow alleviate renal aging.Semantic proximity Read ↗

Aging and senescence-associated analysis of the aged kidney glomerulus highlights the role of mesangial cells in renal agingSemantic proximity Read ↗

Identification of novel genes associated with renal tertiary lymphoid organ formation in aging mice.Semantic proximity Read ↗

Young adult donor bone marrow infusions into female mice postpone age-related reproductive failure and improve offspring survivalSemantic proximity Read ↗

Gender-specific effects of endogenous testosterone: female alpha-estrogen receptor-deficient C57Bl/6J mice develop glomerulosclerosis.Semantic proximity Read ↗

Strain- and Diet-Related Lesion Variability in Aging DBA/2, C57BL/6, and DBA/2xC57BL/6 F1 Mice.Semantic proximity Read ↗

Castrated autoimmune glomerulonephritis mouse model shows attenuated glomerular sclerosis with altered parietal epithelial cell phenotype.Semantic proximity Read ↗

Cardiovascular Benefits of Menopause Hormone Treatment is Age-DependentSemantic proximity Read ↗

Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis.Semantic proximity Read ↗

Proteomic and transcriptomic profiling reveal different aspects of aging in the kidneySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.