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Article

The glomerulosclerosis of aging in females: contribution of the proinflammatory mesangial cell phenotype to macrophage infiltration.

The American journal of pathology - 1 Nov 2004

Zheng Feng, Cheng Qing-Li, Plati Anna-Rita, Ye Shui Qin, Berho Mariana, Banerjee Anita, Potier Mylene, Jaimes Edgar A, Yu Hong, Guan You-Fei, Hao Chung-Ming, Striker Liliane J, Striker Gary E

Abstract excerpt

Age-associated renal changes may be an important cause of renal failure. We recently found that aged female B6 mice developed progressive glomerular lesions. This was associated with macrophage infiltration, a frequent finding in glomerulosclerosis. We used these mice as a model for studying the mechanisms of glomerular aging. We compared the gene expression profile of intact glomeruli from late postmenopausal...

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PMID: 15509547
DOI: 10.1016/S0002-9440(10)63434-7
PMCID: PMC1618669

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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