Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inactivation of FGF8 in early mesoderm reveals an essential role in kidney development.

Development (Cambridge, England) - 1 Sept 2005

Perantoni Alan O, Timofeeva Olga, Naillat Florence, Richman Charmaine, Pajni-Underwood Sangeeta, Wilson Catherine, Vainio Seppo, Dove Lee F, Lewandoski Mark

Abstract excerpt

To bypass the essential gastrulation function of Fgf8 and study its role in lineages of the primitive streak, we have used a new mouse line, T-Cre, to generate mouse embryos with pan-mesodermal loss of Fgf8 expression. Surprisingly, despite previous models in which Fgf8 has been assigned a pivotal role in segmentation/somite differentiation, Fgf8 is not required for these processes. However, mutant neonates...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Lineage
Share to Fibroblast Growth Factor 8

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblast Growth Factors

Share to LIM-Homeodomain Proteins

Share to Limb Buds

Share to Mesoderm

Share to Wnt Proteins

Share to Wnt4 Protein

Source

Identifiers

PMID: 16049111
DOI: 10.1242/dev.01945

Genes

FGF8
WNT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inactivation of FGF8 in early mesoderm reveals an essential role in kidney development.PMID 16049111Read ↗

FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons.Semantic proximity Read ↗

Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development.Semantic proximity Read ↗

Conserved and Divergent Molecular and Anatomic Features of Human and Mouse Nephron PatterningSemantic proximity Read ↗

The Cellular Basis of Kidney DevelopmentSemantic proximity Read ↗

Forming nephrons promote nephron progenitor maintenance and branching morphogenesis via paracrine BMP4 signalling under the control of <i>Wnt4</i>Semantic proximity Read ↗

Disruption of Hox9,10,11 function results in cellular level lineage infidelity in the kidney.Semantic proximity Read ↗

FGF is essential for both condensation and mesenchymal–epithelial transition stages of pronephric kidney tubule developmentSemantic proximity Read ↗

BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning.Semantic proximity Read ↗

The ECM protein nephronectin promotes kidney development via integrin alpha8beta1-mediated stimulation of Gdnf expression.Semantic proximity Read ↗

Notch is required for the formation of all nephron segments and primes nephron progenitors for differentiationSemantic proximity Read ↗

High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor populationSemantic proximity Read ↗

Nephron Patterning: Lessons from Xenopus, Zebrafish, and Mouse StudiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.