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Article

BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning.

Genes & development - 15 Nov 1995

Luo G, Hofmann C, Bronckers A L, Sohocki M, Bradley A, Karsenty G

Abstract excerpt

Bone morphogenetic proteins (BMPs) are multifunctional growth factors originally identified by their ability to induce ectopic bone formation. To investigate the function of one of the BMPs, BMP-7, we have generated BMP-7-deficient mice using embryonic stem cell technology. BMP-7-deficient mice die shortly after birth because of poor kidney development. Histological analysis of mutant embryos at several stages of...

Topics

Animals
Bone Morphogenetic Protein 7
Bone Morphogenetic Proteins
Eye
Female
Kidney
Mice
Mice, Inbred C57BL
Phenotype
Proteins
Transforming Growth Factor beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7590255
DOI: 10.1101/gad.9.22.2808

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7590255-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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