Article
Vasodilator-stimulated phosphoprotein activation of serum-response element-dependent transcription occurs downstream of RhoA and is inhibited by cGMP-dependent protein kinase phosphorylation.
The Journal of biological chemistry - 12 Mar 2004
Zhuang Shunhui, Nguyen Giao T, Chen Yongchang, Gudi Tanima, Eigenthaler Martin, Jarchau Thomas, Walter Ulrich, Boss Gerry R, Pilz Renate B
Abstract excerpt
Vasodilator-stimulated phosphoprotein (VASP) associates with cytoskeletal structures and promotes F-actin formation. RhoA, a member of the Ras superfamily of proteins, activates serum response element (SRE)-dependent transcription through changes in actin dynamics. We now show that the F-actin binding region of VASP is required for VASP stimulation of SRE-dependent transcription, and that VASP is downstream of...
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