Article
The src-family kinase inhibitor PP2 suppresses the in vitro invasive phenotype of bladder carcinoma cells via modulation of Akt.
BJU international - 1 Aug 2005
Chiang George J, Billmeyer Brian R, Canes David, Stoffel John, Moinzadeh Alireza, Austin Christina A, Kosakowski Monika, Rieger-Christ Kimberly M, Libertino John A, Summerhayes Ian C
Abstract excerpt
OBJECTIVE: To evaluate PP2 as a modulator of the cadherin/catenin complex in late-stage bladder carcinoma cells, and to assess its potential invasion-suppressor activity in this model. MATERIALS AND METHODS: A panel of five human bladder carcinoma cells, characterizing late-stage disease, was used to determine the concentration for 50% inhibition of PP2 in cell-proliferation assays. Modulation of cadherin/catenin...
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