Article
Further evidence for the association between a polymorphism in the promoter region of SLC6A3/DAT1 and ADHD: findings from a sample of adults.
European archives of psychiatry and clinical neuroscience - 1 Aug 2014
de Azeredo Lucas A, Rovaris Diego L, Mota Nina R, Polina Evelise R, Marques Francine Z, Contini Verônica, Vitola Eduardo S, Belmonte-de-Abreu Paulo, Rohde Luis A, Grevet Eugenio H, Bau Claiton H D
Abstract excerpt
The dopamine transporter (SLC6A3/DAT1) plays a key role in the regulation of dopaminergic neurotransmission and is the major site of action for methylphenidate, a first-line medication for attention deficit hyperactivity disorder (ADHD). Most genetic association studies with ADHD have investigated a 40-bp variable number of tandem repeats (VNTR) polymorphism in the 3'-untranslated region (UTR) of the DAT1, but...
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