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Article

Global variation of a 40-bp VNTR in the 3'-untranslated region of the dopamine transporter gene (SLC6A3).

Biological psychiatry - 15 Jul 1999

Kang A M, Palmatier M A, Kidd K K

Abstract excerpt

BACKGROUND: The dopamine transporter (DAT) is the primary mechanism for dopamine clearance from the synapse in midbrain dopaminergic neurons, and the target of psychostimulant and neurotoxic drugs such as cocaine, amphetamine, and MPTP. Consequently, the gene for DAT (SLC6A3) has been the focus of many population-based case-control association studies using a 40-bp VNTR in the 3'-untranslated region. Results have...

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PMID: 10418689
DOI: 10.1016/s0006-3223(99)00101-8

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