Article
5' and 3' region variability in the dopamine transporter gene (SLC6A3), pesticide exposure and Parkinson's disease risk: a hypothesis-generating study.
Human molecular genetics - 15 Oct 2006
Kelada Samir N P, Checkoway Harvey, Kardia Sharon L R, Carlson Christopher S, Costa-Mallen Paola, Eaton David L, Firestone Jordan, Powers Karen M, Swanson Phillip D, Franklin Gary M, Longstreth W T, Weller Terri-Smith, Afsharinejad Zahra, Costa Lucio G
Abstract excerpt
The dopamine transporter gene (SLC6A3) is a candidate gene for Parkinson's disease (PD) on the basis of its critical role in dopaminergic neurotransmission. Previously, we identified 22 SNPs in the 5' region of SLC6A3, which segregate as eight haplotypes that differ in transcriptional activity when transfected in rat dopamine-producing cells. In the present work from a case-control study size of 293 cases and 395...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.