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Article

Asp578 in LEU4p is one of the key residues for leucine feedback inhibition release in sake yeast.

Bioscience, biotechnology, and biochemistry - 1 Jul 2005

Oba Takahiro, Nomiyama Shuji, Hirakawa Hideki, Tashiro Kosuke, Kuhara Satoru

Abstract excerpt

We identified a new mutation, Asp578Tyr, in alpha-isopropylmalate synthase (a LEU4 gene product) that releases leucine feedback inhibition and causes hyperproduction of isoamyl alcohol (i-AmOH) in sake yeast. Spontaneous sake yeast mutants that express resistance to 5,5,5-trifluoro-DL-leucine (TFL) were isolated, and a mutant strain, TFL20, was characterized at the genetic and biochemical levels. An enzyme assay...

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Identifiers

PMID: 16041129
DOI: 10.1271/bbb.69.1270

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Asp578 in LEU4p is one of the key residues for leucine feedback inhibition release in sake yeast.PMID 16041129Read ↗

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