Article
Evidence that intramolecular interactions are involved in masking the activation domain of transcriptional activator Leu3p.
The Journal of biological chemistry - 1 Aug 1997
Wang D, Hu Y, Zheng F, Zhou K, Kohlhaw G B
Abstract excerpt
The Leu3 protein of Saccharomyces cerevisiae regulates the expression of genes involved in branched chain amino acid biosynthesis and in ammonia assimilation. It is modulated by alpha-isopropylmalate, an intermediate in leucine biosynthesis. In the presence of alpha-isopropylmalate, Leu3p is a tr...
Topics
- Amino Acid Sequence
- Binding Sites
- DNA-Binding Proteins
- Fungal Proteins
- Molecular Sequence Data
- Mutation
- Protein Structure, Secondary
- Saccharomyces cerevisiae Proteins
- Structure-Activity Relationship
- Trans-Activators