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Article

Evidence that intramolecular interactions are involved in masking the activation domain of transcriptional activator Leu3p.

The Journal of biological chemistry - 1 Aug 1997

Wang D, Hu Y, Zheng F, Zhou K, Kohlhaw G B

Abstract excerpt

The Leu3 protein of Saccharomyces cerevisiae regulates the expression of genes involved in branched chain amino acid biosynthesis and in ammonia assimilation. It is modulated by alpha-isopropylmalate, an intermediate in leucine biosynthesis. In the presence of alpha-isopropylmalate, Leu3p is a transcriptional activator. In the absence of the signal molecule, the activation domain is masked, and Leu3p acts as a...

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Identifiers

PMID: 9235937
DOI: 10.1074/jbc.272.31.19383

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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