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Article

Germ Cells Are Not Required to Establish the Female Pathway in Mouse Fetal Gonads

16 Oct 2012

Abstract excerpt

The fetal gonad is composed of a mixture of somatic cell lineages and germ cells. The fate of the gonad, male or female, is determined by a population of somatic cells that differentiate into Sertoli or granulosa cells and direct testis or ovary development. It is well established that germ cells are not required for the establishment or maintenance of Sertoli cells or testis cords in the male gonad. However, in...

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PMID: 23091613
DOI: 10.1371/journal.pone.0047238

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