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Oxidative stress in myotonic dystrophy type 1

1 Jul 2005

Abstract excerpt

Myotonic dystrophy type 1 (DM1) is the most common form of muscular dystrophy affecting adults. The genetic basis of DM1 consists of a mutational expansion of a repetitive trinucleotide sequence (CTG). The number of triplets expansion divides patients in four categories related to the molecular changes (E1, E2, E3, E4). The pathogenic mechanisms of multi-systemic involvement of DM1 are still unclear. DM1 has been...

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PMID: 16036357
DOI: 10.1080/10715760500138932

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