Article
Patient-derived fibroblasts indicate oxidative stress status and may justify antioxidant therapy in OXPHOS disorders.
Biochimica et biophysica acta - 1 Nov 2012
Voets A M, Lindsey P J, Vanherle S J, Timmer E D, Esseling J J, Koopman W J H, Willems P H G M, Schoonderwoerd G C, De Groote D, Poll-The B T, de Coo I F M, Smeets H J M
Abstract excerpt
Oxidative phosphorylation disorders are often associated with increased oxidative stress and antioxidant therapy is frequently given as treatment. However, the role of oxidative stress in oxidative phosphorylation disorders or patients is far from clear and consequently the preventive or therapeutic effect of antioxidants is highly anecdotic. Therefore, we performed a systematic study of a panel of oxidative...
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