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Article

[Importance of a thymus dysfunction in the pathophysiology of type 1 diabetes].

Revue medicale de Liege - 1 Jan 2000

Geenen V, Brilot F, Louis C, Hansenne I, Renard Ch, Martens H

Abstract excerpt

The autoimmune nature of the diabetogenic process and the major contribution of T lymphocytes stand now beyond any doubt. However, despite the identification of the three major type 1-diabetes-related autoantigens (insulin, GAD65 and phosphatase IA-2), the origin of this immune dysregulation still remains unknown. More and more evidence supports a thymic dysfunction in the establishment of central self-tolerance...

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Share to Autoantigens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16035283

Genes

IGF2
IGF1
INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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